… two antitumor-active trans-oriented complexes, trans-EE and … , trans-[PtCl 2 (E-iminoether)
2 ] (trans-EE) and trans-[PtCl 2 (… a ternary complex trans-[Pt(E-iminoether) 2 (H1 N90 )(DNA)] …

… with significant antitumor activity and, being their DNA-binding … , trans-[PtCl 2 (E-iminoether)
2 ] (trans-EE), trans-[PtCl 2 (NH 3 … The first transformation led to formation of an intermediate …

… processes responsible for their anticancer properties. In this … formed by the transformation of
DNA monofunctional and intrastrand … that inhibition of DNA replication and transcription is an …

… kinetics of DNA adduct formation and antitumor activity [58]. … complex with iminoethers
trans-[PtCl 2 (E-iminoether) 2 ] (trans-EE… Trans-[PtCl 2 (ipa)(dma)] exhibited no antitumor activity in …

… bacteria and eukaryote, including DNA replication, transcription, and translation. It is well-…
antitumor antibiotics, though many orthogonal variations do exist between the two. (24,25) …

… lead compound, bifunctional [{trans-PtCl(NH 3 ) 2 } 2 μ-trans-Pt(NH 3 ) 2 {H 2 N(CH 2 ) 6 NH
… ) versus temperature profiles for the thermally induced transitions of non-modified duplexes (…

… therapy also contains some side effects such as diarrhea, liver … anticancer drug was born
in 16th November 1926 and died in 8th … Different types anticancer agents of Pt (II) and Pt (IV) …

… by exposure to various anti-tumor drugs, transition metals, and … -linked to DNA via cisplatin
or trans-[PtCl 2 (E-iminoether) 2 ]. … to antitumor drugs and formed at epigenetic DNA marks, …

… The large choice of transition metals, oxidation states… 2 (H 2 O) 2 ] 2+ species that bind to
nuclear DNA distorting the helical structure, and interfere with DNA replication and transcription …

… They are also formed by anticancer agents such as nitrogen mustard [6] and … affect DNA
transactions, such as replication and transcription, and how cells mitigate their adverse effects. …